Recent Progress in the Cyp 51 Research Focusing on Its Unique Evolutionary and Functional Characteristics
نویسنده
چکیده
1. Abstract 2. Introduction 3. CYP51 is an example showing the diversification process of P450 3.1. Different substrate specificity of fungal, plant, and animal CYP51s is an example of P450 diversification 3.2. Formation of C. albicans CYP51 variants through the interaction with environmental azole antifungal agents 4. Structural analysis of CYP51 4.1. Structural examination of CYP51 with site-directed mutagenesis 4.2. The X-ray crystallographic analysis of M. tuberculosis CYP51 5. Summary and perspective 6. Acknowledgements 7. References
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